6,555 research outputs found

    Rejecting another pains the self: The impact of perceived future rejection

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    The current investigation examined whether people would experience a higher level of pain after rejecting another person, especially for those high in evaluative concern, through increased perceptions of future rejection. Three experiments provide converging support to these predictions. After reliving a past rejecting experience (Experiments 1 and 2) and concurrently rejecting another person (Experiment 3), the source of rejection experienced a higher level of pain than participants in the control conditions. We also found that evaluative concern, either primed (Experiment 2) or measured (Experiment 3) moderated the above effect, such that this effect was only observed among participants high in evaluative concern, but not among those low in evaluative concern. Moreover, perceived future rejection mediated the moderating effect of evaluative concern and rejecting another person on the levels of pain that people experience (Experiment 3). These findings contribute to the literature by showing a mechanism explaining why rejecting another person pains the self and who are more susceptible to this influence.postprin

    Estimation of Time-varying Frequency and its Rate of Change in Low-inertia Power Systems

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    In this paper, a hierarchical estimation scheme is designed to track the frequency and its rate of change of non-stationary power signals. The frequency is retrieved by a kernel-based parameter estimator in the first step. Subsequently, the frequency estimates are injected into a kernel-based numerical differentiator to extract its changing rate. Thanks to the deployed Volterra integral operator and suitably designed kernel-functions, the proposed estimator can achieve very fast convergence speed without compromising the robustness against noise. Therefore, the real-time estimates are able to follow the time-varying frequency and its rate of change with satisfactory accuracy. The effectiveness and robustness of the proposed method are verified by numerical experiments considering typical practical scenarios under the disturbance of noise. The results of the proposed method are compared with a highly-concerned quadrature phase-locked-loop (QPLL) method

    Benchmarking network-based gene prioritization methods for cerebral small vessel disease

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    Network-based gene prioritization algorithms are designed to prioritize disease-associated genes based on known ones using biological networks of protein interactions, gene disease associations and other relationships between biological entities. Various algorithms have been developed based on different mechanisms, but it is not obvious which algorithm is optimal for a specific disease. To address this issue, we benchmarked multiple algorithms for their application in cerebral small vessel disease (cSVD). We curated protein-gene interactions (PGI) and gene-disease associations (GDA) from databases and assembled PGI networks and disease-gene heterogenous networks. A screening of algorithms resulted in seven representative algorithms to be benchmarked. Performance of algorithms was assessed using both leave-one-out cross-validation (LOOCV) and external validation with MEGASTROKE genome-wide association study (GWAS). We found that random walk with restart on the heterogeneous network (RWRH) showed best LOOCV performance, with median LOOCV rediscovery rank of 185.5 (out of 19,463 genes). The GenePanda algorithm had most GWAS-confirmable genes in top 200 predictions, while RWRH had best ranks for small vessel stroke associated genes confirmed in GWAS. In conclusion, RWRH has overall better performance for application in cSVD despite its susceptibility to bias caused by degree centrality. Choice of algorithms should be determined before applying to specific disease. Current pure network-based gene prioritization algorithms are unlikely to find novel disease-associated genes that are not associated with known ones. The tools for implementing and benchmarking algorithms have been made available and can be generalized for other diseases

    HA-grid: security aware hazard analysis for smart grids

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    Attacks targeting smart grid infrastructures can result in the disruptions of power supply as well as damages to costly equipment, with significant impact on safety as well as on end-consumers. It is therefore of essence to identify attack paths in the infrastructure that lead to safety violations and to determine critical components that must be protected. In this paper, we introduce a methodology (HA-Grid) that incorporates both safety and security modelling of smart grid infrastructure to analyse the impact of cyber threats on the safety of smart grid infrastructures. HA-Grid is applied on a smart grid test-bed to identify attack paths that lead to safety hazards, and to determine the common nodes in these attack paths as critical components that must be protected

    Nickel isotopic evidence for late-stage accretion of Mercury-like differentiated planetary embryos

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    Earth’s habitability is closely tied to its late-stage accretion, during which impactors delivered the majority of life-essential volatiles. However, the nature of these final building blocks remains poorly constrained. Nickel (Ni) can be a useful tracer in characterizing this accretion as most Ni in the bulk silicate Earth (BSE) comes from the late-stage impactors. Here, we apply Ni stable isotope analysis to a large number of meteorites and terrestrial rocks, and find that the BSE has a lighter Ni isotopic composition compared to chondrites. Using first-principles calculations based on density functional theory, we show that core-mantle differentiation cannot produce the observed light Ni isotopic composition of the BSE. Rather, the sub-chondritic Ni isotopic signature was established during Earth’s late-stage accretion, probably through the Moon-forming giant impact. We propose that a highly reduced sulfide-rich, Mercury-like body, whose mantle is characterized by light Ni isotopic composition, collided with and merged into the proto-Earth during the Moon-forming giant impact, producing the sub-chondritic Ni isotopic signature of the BSE, while delivering sulfur and probably other volatiles to the Earth
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